Abstract
The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues.
Keywords:
circadian clocks; metabolic disease; metabolism.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ARNTL Transcription Factors / genetics
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ARNTL Transcription Factors / metabolism
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Adipose Tissue / metabolism
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Adipose Tissue / physiopathology
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Animals
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Body Temperature
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Circadian Clocks*
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Energy Metabolism*
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Glucose / metabolism
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Humans
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Hypothalamus / metabolism
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Hypothalamus / physiopathology
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Lipid Metabolism
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Liver / metabolism
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Liver / physiopathology
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Metabolic Diseases / genetics
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Metabolic Diseases / metabolism
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Metabolic Diseases / physiopathology*
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiopathology
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Pancreas / metabolism
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Pancreas / physiopathology
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Risk Factors
Substances
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ARNTL Transcription Factors
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Glucose