Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis

J Neuroimmunol. 2013 Jan 15;254(1-2):174-7. doi: 10.1016/j.jneuroim.2012.09.003. Epub 2012 Sep 23.

Abstract

We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genes, MHC Class II / genetics*
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA-DRB3 Chains / genetics*
  • HLA-DRB4 Chains / genetics
  • HLA-DRB5 Chains / genetics
  • Humans
  • Linkage Disequilibrium*
  • Logistic Models
  • Male
  • Middle Aged
  • Myositis, Inclusion Body / genetics*

Substances

  • HLA-DRB3 Chains
  • HLA-DRB4 Chains
  • HLA-DRB5 Chains