Cell adhesion: a FERM grasp of the tail sorts out integrins

Curr Biol. 2012 Sep 11;22(17):R692-4. doi: 10.1016/j.cub.2012.07.049.

Abstract

As well as modulating integrin activation, a conserved NPxY motif in integrin cytoplasmic tails that binds the FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycling and degradation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cytoskeletal Proteins / physiology*
  • Integrin alpha5beta1 / physiology*
  • Muscle Proteins / physiology*
  • Talin / physiology*

Substances

  • Cytoskeletal Proteins
  • Integrin alpha5beta1
  • Muscle Proteins
  • Talin
  • kindlin-2 protein, mouse
  • Tln1 protein, mouse