Neural regeneration in Caenorhabditis elegans

Annu Rev Genet. 2012:46:499-513. doi: 10.1146/annurev-genet-110711-155550. Epub 2012 Sep 4.

Abstract

Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / physiology*
  • Axotomy / methods
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Calcium Channels / metabolism
  • Cyclic AMP / metabolism
  • MAP Kinase Kinase Kinases / genetics
  • MAP Kinase Kinase Kinases / metabolism
  • MAP Kinase Signaling System
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Microtubules / metabolism
  • Models, Animal
  • Nerve Regeneration*
  • Neurons / metabolism
  • Neurons / physiology
  • Trauma, Nervous System / metabolism
  • Trauma, Nervous System / physiopathology

Substances

  • Caenorhabditis elegans Proteins
  • Calcium Channels
  • EFA-6 protein, C elegans
  • MicroRNAs
  • Cyclic AMP
  • DLK-1 protein, C elegans
  • MAP Kinase Kinase Kinases