Preparation for discharge begins prior to the admission for bone marrow transplant. Assessment of the home environment and the effect of prolonged isolation on the life style of the patient and family are important factors. Once the transplant process has been accomplished and the patient meets the criteria for discharge, physical preparation of the home environment can begin. In the immediate post-transplant period, treatment or prophylaxis of graft-versus-host disease (GVHD) is monitored. Immune globulins may be replaced every three to four weeks. Long-term follow-up often continues for many years, especially when chronic GVHD is present. Continued psychosocial support is needed throughout this process to prepare the patient for re-entry into the community.