Decidual stromal cells as regulators of T-cell access to the maternal-fetal interface

Am J Reprod Immunol. 2012 Oct;68(4):279-81. doi: 10.1111/aji.12006. Epub 2012 Aug 31.

Abstract

A recent study in the journal Science offers insights into the mechanism behind feto-maternal tolerance, as evidenced by changes in the immuno-logical environment of the uterus and decidua. They also provide a rich area of research for the understanding of the regulation of the immune system in other complicated medical conditions, including cancer and pregnancies affected by infection or autoimmunity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Communication
  • Cell Movement / drug effects
  • Cellular Microenvironment
  • Chemokine CXCL10 / metabolism
  • Chemokine CXCL9 / metabolism
  • Female
  • Humans
  • Immune Tolerance
  • Immunomodulation
  • Maternal-Fetal Exchange / immunology*
  • Phenanthridines / immunology*
  • Pregnancy
  • Stromal Cells / immunology*
  • T-Lymphocytes / immunology*
  • Th1-Th2 Balance

Substances

  • Chemokine CXCL10
  • Chemokine CXCL9
  • Phenanthridines
  • decidium