Prevention of HLA alloimmunization: role of leukocyte depletion and UV-B irradiation

Yale J Biol Med. 1990 Sep-Oct;63(5):419-27.

Abstract

HLA alloimmunization is a major cause of the platelet refractory state. The stimulus for HLA alloimmunization is believed to derive from incompatibility between the recipient's lymphocytes and the passenger donor lymphocytes contained in transfused red cells or platelet concentrates. Two techniques to prevent post-transfusion HLA alloimmunization include filtration, which physically removes the donor lymphocytes, and UV-B irradiation, which renders the donor leukocytes biologically inactive. The role of these two techniques in the prevention of HLA alloimmunization is the focus of this review.

Publication types

  • Review

MeSH terms

  • Animals
  • Dogs
  • HLA Antigens / immunology*
  • Humans
  • Isoantibodies / biosynthesis*
  • Leukapheresis
  • Leukocytes / immunology*
  • Platelet Transfusion*
  • Quality Control
  • Transfusion Reaction*
  • Ultraviolet Rays

Substances

  • HLA Antigens
  • Isoantibodies