Implementation of false discovery rate for exploring novel paradigms and trait dimensions with ERPs

Dev Neuropsychol. 2012;37(6):559-77. doi: 10.1080/87565641.2012.694513.

Abstract

False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportion of false discoveries among the discoveries. Employing FDR methods in event-related potential (ERP) research provides an approach to explore new ERP paradigms and ERP-psychological trait/behavior relations. In Study 1, we examined neural responses to escape behavior from an aversive noise. In Study 2, we correlated a relatively unexplored trait dimension, ostracism, with neural response. In both situations we focused on the frontal cortical region, applying a channel by time plots to display statistically significant uncorrected data and FDR corrected data, controlling for multiple comparisons.

MeSH terms

  • Adolescent
  • Brain Mapping / methods*
  • Child
  • Escape Reaction / physiology*
  • Evoked Potentials / physiology*
  • Female
  • Frontal Lobe / physiology*
  • Humans
  • Male
  • Personality / physiology*
  • Principal Component Analysis
  • Research Design
  • Young Adult