Chromatin and pluripotency: the MYSTerious connection

Cell Stem Cell. 2012 Aug 3;11(2):139-40. doi: 10.1016/j.stem.2012.07.013.

Abstract

Although histone acetylation is critical for maintaining embryonic stem cell pluripotency, the molecular machinery involved remains poorly understood. Li et al. (2012) now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of Nanog-mediated transcription, maintains the expression of pluripotency-associated genes, and primes developmental genes for differentiation.

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