Global connectivity of prefrontal cortex predicts cognitive control and intelligence

J Neurosci. 2012 Jun 27;32(26):8988-99. doi: 10.1523/JNEUROSCI.0536-12.2012.

Abstract

Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism--global connectivity--by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping*
  • Cognition / physiology*
  • Female
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted
  • Individuality
  • Intelligence / physiology*
  • Intelligence Tests
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways / blood supply
  • Neural Pathways / physiology*
  • Neuropsychological Tests
  • Oxygen / blood
  • Predictive Value of Tests
  • Prefrontal Cortex / blood supply
  • Prefrontal Cortex / physiology*
  • Young Adult

Substances

  • Oxygen