Abstract
COP1 and DET1 are among the first repressors of photomorphogenesis to be identified, more than 20 years ago. Discovery of these repressors as conserved regulators of the ubiquitin-proteasome system has established protein degradation as a central theme in light signal transduction. COP1 is a RING E3 ubiquitin ligase that targets key regulators for degradation, and DET1 complexes with COP10 and DDB1, which is proposed to aid in COP1-mediated degradation. Recent studies have strengthened the role of COP1 as a major signaling center. DET1 is also emerging as a chromatin regulator in repressing gene expression. Here, we review current understanding on COP1 and DET1, with a focus on their role as part of two distinct, multimeric CUL4-based E3 ligases.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Arabidopsis / enzymology
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Arabidopsis / genetics
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Arabidopsis / radiation effects
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism*
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Circadian Rhythm
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Cullin Proteins / genetics
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Cullin Proteins / metabolism
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Flowers / genetics
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Flowers / metabolism
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Gene Expression Regulation, Plant
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Genes, Plant
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Genetic Loci
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Intracellular Signaling Peptides and Proteins
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Light
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Plant Development / radiation effects*
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Proteolysis
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Signal Transduction
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Transcription, Genetic
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism*
Substances
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Arabidopsis Proteins
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CULLIN4 protein, Arabidopsis
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Cullin Proteins
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DET1 protein, Arabidopsis
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Intracellular Signaling Peptides and Proteins
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Nuclear Proteins
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Repressor Proteins
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AT2G32950 protein, Arabidopsis
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Ubiquitin-Protein Ligases