Rhodium-catalyzed synthesis of branched amines by direct addition of benzamides to imines

Org Lett. 2012 May 4;14(9):2304-7. doi: 10.1021/ol300723x. Epub 2012 Apr 13.

Abstract

Rhodium-catalyzed addition of benzamide C-H bonds to a range of aromatic N-sulfonyl aldimines has been developed and proceeds with high functional group compatibility. The synthetic utility of the resulting branched amine products has also been demonstrated by the preparation of isoindoline and isoindolinone frameworks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amines / chemical synthesis*
  • Amines / chemistry
  • Benzamides / chemistry*
  • Catalysis
  • Imines / chemical synthesis*
  • Imines / chemistry
  • Isoindoles / chemical synthesis
  • Isoindoles / chemistry
  • Molecular Structure
  • Rhodium / chemistry*

Substances

  • Amines
  • Benzamides
  • Imines
  • Isoindoles
  • Rhodium