Exploiting effectors of Rac GTPase

Chem Biol. 2012 Feb 24;19(2):169-71. doi: 10.1016/j.chembiol.2012.02.001.

Abstract

Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Biology, Bosco et al. exploit the interactive interface between Rac GTPase and its effector p67(phox) to specifically inhibit reactive oxygen species production without perturbing other Rac-mediated cellular processes.

Publication types

  • Comment

MeSH terms

  • Benzoxazines / pharmacology*
  • Drug Design*
  • Humans
  • Inflammation / metabolism*
  • Phosphoproteins / antagonists & inhibitors*
  • Pyrazoles / pharmacology*
  • Signal Transduction / drug effects*
  • rac GTP-Binding Proteins / antagonists & inhibitors*

Substances

  • Benzoxazines
  • Phosphoproteins
  • Phox-I1
  • Pyrazoles
  • neutrophil cytosol factor 67K
  • rac GTP-Binding Proteins