Placental origins of angiogenic dysfunction in mirror syndrome

Hypertens Pregnancy. 2012;31(2):211-7. doi: 10.3109/10641955.2011.638959. Epub 2011 Dec 9.

Abstract

BACKGROUNDL: Mirror syndrome is characterized by preeclampsia-like syndrome in pregnancies complicated by fetal hydrops. We describe a case of mirror syndrome associated with angiogenic dysfunction in maternal plasma and the placenta.

Case: A pregnant patient with known fetal hydrops presented at 22 weeks gestation with features of severe preeclampsia. Measurements of plasma anti- and proangiogenic factors were consistent with a profound antiangiogenic state. Immunohistochemistry of the placenta for antiangiogenic proteins showed a pattern similar to that seen in patients with severe preeclampsia.

Conclusion: Angiogenic imbalance may also be responsible for the preeclampsia-like condition seen in mirror syndrome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD / blood
  • Biomarkers / blood*
  • Endoglin
  • Female
  • Humans
  • Hydrops Fetalis / physiopathology*
  • Placenta / metabolism*
  • Placenta Growth Factor
  • Pre-Eclampsia / etiology*
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Pregnancy Proteins / blood
  • Receptors, Cell Surface / blood
  • Vascular Endothelial Growth Factor Receptor-1 / blood

Substances

  • Antigens, CD
  • Biomarkers
  • ENG protein, human
  • Endoglin
  • PGF protein, human
  • Pregnancy Proteins
  • Receptors, Cell Surface
  • Placenta Growth Factor
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1