The expansion of access to antiretroviral therapy for millions of persons living with HIV in low-income countries has been lauded by many. However, the investment in such programs has at the same time been criticized by others, who claim diversion of resources from HIV prevention efforts and from other important health threats in these same countries. Yet, the time is right to recommit to the goal of universal access to HIV prevention and treatment while garnering the lessons learned from HIV programming and building on the platform it has established in confronting other health threats.