Structure of Golgi transport proteins

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12):a007609. doi: 10.1101/cshperspect.a007609.

Abstract

The function of the Golgi has long been recognized to critically depend on vesicular transport from, to, and within its cisternae, involving constant membrane fission and fusion. These processes are mediated by Arf GTPases and coat proteins, and Rabs, tethers and SNARE proteins, respectively. In this article, we describe structural studies of Golgi coats and tethers and their interactions with SNAREs and GTPases as well as insights regarding membrane traffic processes that these have provided.

Publication types

  • Review

MeSH terms

  • Clathrin-Coated Vesicles / chemistry
  • Clathrin-Coated Vesicles / metabolism
  • Clathrin-Coated Vesicles / physiology
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism
  • Fungal Proteins / physiology
  • Golgi Apparatus / metabolism*
  • Humans
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology
  • Models, Biological
  • Protein Structure, Tertiary
  • Protein Transport
  • Vesicular Transport Proteins / chemistry
  • Vesicular Transport Proteins / metabolism
  • Vesicular Transport Proteins / physiology

Substances

  • Fungal Proteins
  • Membrane Proteins
  • Vesicular Transport Proteins