Biochemistry. KSR plays CRAF-ty

Science. 2011 May 27;332(6033):1043-4. doi: 10.1126/science.1208063.

Authors

Fumin Shi¹, Mark A Lemmon

Affiliation

¹ Department of Biochemistry and Biophysics, and Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104-6059, USA.

PMID: 21617065
DOI: 10.1126/science.1208063

No abstract available

MeSH terms

Allosteric Regulation
Animals
Binding Sites
Catalytic Domain
Cell Membrane / enzymology
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases / metabolism*
Humans
MAP Kinase Signaling System*
Mitogen-Activated Protein Kinase Kinases / metabolism*
Mutation
Phosphorylation
Protein Conformation
Protein Kinases / chemistry
Protein Kinases / genetics
Protein Kinases / metabolism*
Protein Multimerization
Protein Structure, Secondary
Protein Structure, Tertiary
Proto-Oncogene Proteins B-raf / antagonists & inhibitors
Proto-Oncogene Proteins B-raf / metabolism*
Proto-Oncogene Proteins c-raf / metabolism*

Substances

Protein Kinases
KSR-1 protein kinase
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinase Kinases