G0 is a major growth cone protein subject to regulation by GAP-43

Nature. 1990 Apr 26;344(6269):836-41. doi: 10.1038/344836a0.

Abstract

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain Chemistry
  • Cell Membrane / analysis
  • GAP-43 Protein
  • GTP-Binding Proteins / metabolism*
  • Growth Substances / physiology*
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Guanosine Triphosphate / analogs & derivatives
  • Guanosine Triphosphate / metabolism
  • Membrane Glycoproteins / physiology*
  • Molecular Sequence Data
  • Molecular Weight
  • Nerve Tissue Proteins / physiology*
  • Peptide Fragments / isolation & purification
  • Peptide Fragments / pharmacology
  • Protein Binding
  • Rats
  • Receptors, Cell Surface
  • Receptors, Neurotransmitter
  • Sequence Homology, Nucleic Acid
  • Signal Transduction
  • Thionucleotides / metabolism

Substances

  • GAP-43 Protein
  • Growth Substances
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Peptide Fragments
  • Receptors, Cell Surface
  • Receptors, Neurotransmitter
  • Thionucleotides
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Guanosine Triphosphate
  • GTP-Binding Proteins