Abstract
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain Chemistry
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Cell Membrane / analysis
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GAP-43 Protein
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GTP-Binding Proteins / metabolism*
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Growth Substances / physiology*
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Guanosine 5'-O-(3-Thiotriphosphate)
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Guanosine Triphosphate / analogs & derivatives
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Guanosine Triphosphate / metabolism
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Membrane Glycoproteins / physiology*
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Molecular Sequence Data
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Molecular Weight
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Nerve Tissue Proteins / physiology*
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Peptide Fragments / isolation & purification
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Peptide Fragments / pharmacology
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Protein Binding
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Rats
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Receptors, Cell Surface
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Receptors, Neurotransmitter
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Sequence Homology, Nucleic Acid
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Signal Transduction
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Thionucleotides / metabolism
Substances
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GAP-43 Protein
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Growth Substances
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Peptide Fragments
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Receptors, Cell Surface
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Receptors, Neurotransmitter
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Thionucleotides
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Guanosine 5'-O-(3-Thiotriphosphate)
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Guanosine Triphosphate
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GTP-Binding Proteins