Coordinating migratory neuron polarization by numb-ing communication

Joshua J Breunig; Pasko Rakic

doi:10.1016/j.devcel.2011.05.002

Coordinating migratory neuron polarization by numb-ing communication

Dev Cell. 2011 May 17;20(5):578-80. doi: 10.1016/j.devcel.2011.05.002.

Authors

Joshua J Breunig¹, Pasko Rakic

Affiliation

¹ Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

PMID: 21571215
DOI: 10.1016/j.devcel.2011.05.002

Abstract

An interplay between intrinsic polarity and extracellular cues guides neuronal migration during cerebellar development. In this issue of Developmental Cell, Zhou et al. (2011) demonstrate that Numb is the focal point in mediating the chemotactic response of migrating cerebellar granule cells to BDNF through its regulation of cell polarity.

Publication types

Comment

Grants and funding

R01 NS014841/NS/NINDS NIH HHS/United States