Abstract
Tumor cell invadopodia mediate degradation of matrix barriers. A new study now demonstrates that a ring of active RhoC focuses invadopodial protrusion and degradation by regulating cofilin activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Actin Depolymerizing Factors / metabolism
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Animals
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology*
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Cell Movement
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Cell Surface Extensions / metabolism
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Female
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Humans
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Phosphorylation
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rho GTP-Binding Proteins / metabolism*
Substances
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Actin Depolymerizing Factors
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rho GTP-Binding Proteins