Invadopodia: RhoC runs rings around cofilin

Curr Biol. 2011 Apr 26;21(8):R280-2. doi: 10.1016/j.cub.2011.03.035.

Abstract

Tumor cell invadopodia mediate degradation of matrix barriers. A new study now demonstrates that a ring of active RhoC focuses invadopodial protrusion and degradation by regulating cofilin activity.

Publication types

  • Comment

MeSH terms

  • Actin Depolymerizing Factors / metabolism
  • Animals
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology*
  • Cell Movement
  • Cell Surface Extensions / metabolism
  • Female
  • Humans
  • Phosphorylation
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Actin Depolymerizing Factors
  • rho GTP-Binding Proteins