Inclusion body myositis: diagnosis, pathogenesis, and treatment options

Rheum Dis Clin North Am. 2011 May;37(2):173-83, v. doi: 10.1016/j.rdc.2011.01.003.

Abstract

Inclusion body myositis (IBM) is the most common acquired myopathy in people older than 50 years. IBM typically presents with distal upper extremity weakness accompanied by proximal lower extremity muscle weakness. Associated clinical findings include asymmetric weakness, foot drop, and dysphagia. The pathogenesis of IBM is not clear. In this article the authors briefly discuss postulated pathogenic mechanisms. Although no proven pharmacotherapy exists, some promising candidates are discussed.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antibodies, Monoclonal / therapeutic use
  • Diagnosis, Differential
  • Etanercept
  • Humans
  • Immunoglobulin G / therapeutic use
  • Muscle, Skeletal / pathology
  • Muscle, Skeletal / physiopathology
  • Myositis, Inclusion Body* / diagnosis
  • Myositis, Inclusion Body* / drug therapy
  • Myositis, Inclusion Body* / etiology
  • Polymyositis / diagnosis
  • Randomized Controlled Trials as Topic
  • Receptors, Tumor Necrosis Factor / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal
  • Immunoglobulin G
  • Receptors, Tumor Necrosis Factor
  • Etanercept