Protein kinase C regulation: C1 meets C-tail

Marcelo G Kazanietz; Mark A Lemmon

doi:10.1016/j.str.2011.01.004

Protein kinase C regulation: C1 meets C-tail

Structure. 2011 Feb 9;19(2):144-6. doi: 10.1016/j.str.2011.01.004.

Authors

Marcelo G Kazanietz¹, Mark A Lemmon

Affiliation

¹ Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. marcelog@upenn.edu

PMID: 21300283
DOI: 10.1016/j.str.2011.01.004

Abstract

In a recent issue of Cell, Leonard et al. (2011) describe the structure of PKCβII, an AGC kinase, revealing an unanticipated intramolecular autoinhibitory interaction between its C-terminal tail and the diacylglycerol and phorbol ester binding site of its C1b domain.

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