Abstract
Caspase-1 plays a key role in host defense through its dual function in inducing a pro-inflammatory cell death termed pyroptosis and in promoting the secretion of pro-inflammatory cytokines. A new study now highlights the specific importance of pyroptosis in resistance to intracellular pathogens.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacteria / genetics
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Bacteria / metabolism
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Caspase 1 / genetics
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Caspase 1 / metabolism
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Cell Death / physiology*
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Cytokines / genetics
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Cytokines / metabolism
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Flagellin / genetics
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Flagellin / metabolism
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Gene Expression Regulation / physiology
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Inflammation / immunology
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Inflammation / metabolism
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Macrophages / immunology
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Macrophages / microbiology*
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Macrophages / physiology*
Substances
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Cytokines
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Flagellin
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Caspase 1