Mitochondrial stress signals revise an old aging theory

Dong Kyun Woo; Gerald S Shadel

doi:10.1016/j.cell.2010.12.023

Mitochondrial stress signals revise an old aging theory

Cell. 2011 Jan 7;144(1):11-2. doi: 10.1016/j.cell.2010.12.023.

Authors

Dong Kyun Woo¹, Gerald S Shadel

Affiliation

¹ Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.

PMID: 21215364
DOI: 10.1016/j.cell.2010.12.023

Abstract

In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.

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Comment
Research Support, N.I.H., Extramural

Abstract

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