Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Cytokine. 2011 Mar;53(3):292-4. doi: 10.1016/j.cyto.2010.12.010. Epub 2011 Jan 3.

Abstract

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Macrophage Migration-Inhibitory Factors / genetics*
  • Male
  • Meningitis, Pneumococcal / genetics*
  • Meningitis, Pneumococcal / microbiology
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic / genetics
  • Risk Factors
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • Macrophage Migration-Inhibitory Factors