Abstract
Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Multicenter Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alleles
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Female
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Gene Frequency
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Genetic Predisposition to Disease / genetics*
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Genotype
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Humans
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Macrophage Migration-Inhibitory Factors / genetics*
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Male
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Meningitis, Pneumococcal / genetics*
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Meningitis, Pneumococcal / microbiology
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Middle Aged
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Polymorphism, Single Nucleotide*
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Promoter Regions, Genetic / genetics
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Risk Factors
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Sequence Analysis, DNA
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Young Adult
Substances
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Macrophage Migration-Inhibitory Factors