Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy

Kidney Int. 2010 Dec;78(11):1060-3. doi: 10.1038/ki.2010.344.

Abstract

Tenofovir, used in combination with other antiretroviral agents, is an effective therapy for HIV infection. Although large clinical studies and post-marketing data support a benign renal profile for tenofovir, numerous cases of kidney injury raise concern for nephrotoxic potential. Early human studies and experimental evidence suggested that tenofovir itself was not associated with mitochondrial toxicity within the kidney. However, recent animal data demonstrate that tenofovir causes mitochondrial DNA depletion and mitochondrial toxicity. Herlitz et al. confirm the nephrotoxicity of tenofovir in humans. They describe its clinical consequences, histopathologic findings, and its mitochondrial toxicity in HIV+ patients.

Publication types

  • Comment

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Adenine / administration & dosage
  • Adenine / adverse effects
  • Adenine / analogs & derivatives*
  • Animals
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects*
  • Drug Administration Schedule
  • Glycosuria / chemically induced
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / pathogenicity*
  • Humans
  • Kidney Tubular Necrosis, Acute / chemically induced*
  • Kidney Tubular Necrosis, Acute / pathology
  • Kidney Tubular Necrosis, Acute / therapy
  • Kidney Tubules, Proximal / drug effects*
  • Kidney Tubules, Proximal / ultrastructure
  • Mitochondria / drug effects*
  • Mitochondria / ultrastructure
  • Organophosphonates / administration & dosage
  • Organophosphonates / adverse effects*
  • Proteinuria / chemically induced
  • Renal Dialysis
  • Renal Insufficiency / chemically induced
  • Tenofovir
  • Time Factors

Substances

  • Anti-HIV Agents
  • Organophosphonates
  • Tenofovir
  • Adenine