Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study

Psychiatry Res. 2010 Dec 30;184(3):192-5. doi: 10.1016/j.pscychresns.2010.08.001. Epub 2010 Nov 3.

Abstract

Dopamine (DA) and serotonin (5-HT) transporter availability in heroin users and healthy controls was measured using [¹²³I]β-CIT and SPECT imaging. Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Brain / diagnostic imaging*
  • Brain / pathology
  • Brain Mapping
  • Chronic Disease
  • Cocaine / analogs & derivatives
  • Dopamine / metabolism*
  • Female
  • Heroin Dependence* / diagnostic imaging
  • Heroin Dependence* / metabolism
  • Heroin Dependence* / pathology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Radiopharmaceuticals
  • Serotonin Plasma Membrane Transport Proteins / metabolism*
  • Tomography, Emission-Computed, Single-Photon*
  • Young Adult

Substances

  • Radiopharmaceuticals
  • Serotonin Plasma Membrane Transport Proteins
  • 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
  • Cocaine
  • Dopamine