Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient

Minerva Gastroenterol Dietol. 2010 Sep;56(3):331-43.

Abstract

Caring for patients with advanced liver disease and acute liver failure requires a thorough understanding of the profound coagulation changes that occur in these conditions. Due to the unique nature of the pathophysiologic changes from hepatic dysfunction, effective interpretation and management of coagulopathy and thrombocytopenia with blood products are important clinical skills, and are likewise required in the post transplant period. Acute superimposed complications such as sepsis and renal dysfunction present additional challenges. The aim of this review was to describe the coagulation changes in liver disease, appropriate coagulation testing, and management strategies in the pre- and post-transplant period.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / surgery
  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation Disorders / etiology
  • Blood Coagulation Disorders / therapy
  • Humans
  • Liver Transplantation*
  • Perioperative Care
  • Postoperative Care
  • Postoperative Complications
  • Preoperative Care
  • Thrombocytopenia / diagnosis*
  • Thrombocytopenia / etiology