A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis

J Neuroimmunol. 2010 Sep 14;226(1-2):192-3. doi: 10.1016/j.jneuroim.2010.06.016. Epub 2010 Jul 23.

Abstract

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies / metabolism*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Central Nervous System / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / pathology*
  • Receptors, Antigen, B-Cell / immunology*

Substances

  • Antibodies
  • Receptors, Antigen, B-Cell