Regulation of ionotropic glutamate receptors by their auxiliary subunits

Physiology (Bethesda). 2010 Feb;25(1):41-9. doi: 10.1152/physiol.00033.2009.

Abstract

Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The elucidation of the molecular rules governing glutamate receptors and subunits will improve our understanding of synapses and of neural-circuit regulation in the brain.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channel Gating*
  • Nervous System Diseases / metabolism
  • Nervous System Diseases / physiopathology
  • Neuronal Plasticity
  • Neurons / metabolism*
  • Protein Conformation
  • Protein Subunits
  • Protein Transport
  • Receptors, AMPA / metabolism
  • Receptors, Glutamate / chemistry
  • Receptors, Glutamate / metabolism*
  • Structure-Activity Relationship
  • Synaptic Transmission

Substances

  • Protein Subunits
  • Receptors, AMPA
  • Receptors, Glutamate
  • alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human