An unnatural PIP simulates growth factor signaling

Chem Biol. 2009 Nov 25;16(11):1127-8. doi: 10.1016/j.chembiol.2009.11.003.

Abstract

In this issue of Chemistry & Biology, Laketa et al. describe the synthesis of a membrane permeant phosphoinositide lipid that acts to stimulate PI(3,4,5)P(3)-dependent signaling without the need of growth factor stimulation.

Publication types

  • Comment

MeSH terms

  • Intercellular Signaling Peptides and Proteins / physiology
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphatidylinositol Phosphates / chemical synthesis
  • Phosphatidylinositol Phosphates / chemistry
  • Phosphatidylinositols / chemical synthesis
  • Phosphatidylinositols / chemistry*
  • Signal Transduction*
  • Structure-Activity Relationship

Substances

  • Intercellular Signaling Peptides and Proteins
  • Phosphatidylinositol Phosphates
  • Phosphatidylinositols
  • phosphatidylinositol 3,4,5-triphosphate
  • phosphatidylinositol 3,4-diphosphate
  • Phosphatidylinositol 3-Kinases