Abstract
In this issue of Chemistry & Biology, Laketa et al. describe the synthesis of a membrane permeant phosphoinositide lipid that acts to stimulate PI(3,4,5)P(3)-dependent signaling without the need of growth factor stimulation.
MeSH terms
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Intercellular Signaling Peptides and Proteins / physiology
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphatidylinositol Phosphates / chemical synthesis
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Phosphatidylinositol Phosphates / chemistry
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Phosphatidylinositols / chemical synthesis
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Phosphatidylinositols / chemistry*
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Signal Transduction*
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Structure-Activity Relationship
Substances
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Intercellular Signaling Peptides and Proteins
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Phosphatidylinositol Phosphates
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Phosphatidylinositols
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phosphatidylinositol 3,4,5-triphosphate
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phosphatidylinositol 3,4-diphosphate
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Phosphatidylinositol 3-Kinases