Enantioselective catalysis and complexity generation from allenoates

Chem Soc Rev. 2009 Nov;38(11):3102-16. doi: 10.1039/b816700c. Epub 2009 Jul 24.

Abstract

Lewis base catalysis of reactions with allenoates using phosphine and amine nucleophiles has emerged as a key platform for the generation of molecular complexity. Investigations in this area have established a range of suitable coupling partners for allenoates, including electron-deficient olefins, imines, and aldehydes. This tutorial review will describe these methodologies, with a special emphasis on recent work regarding asymmetric reactions using chiral Lewis base catalysts.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alkadienes / chemistry*
  • Catalysis
  • Organic Chemistry Phenomena
  • Stereoisomerism

Substances

  • Alkadienes