Abstract
Campylobacter jejuni is a leading cause of food-borne illness in the United States. Despite significant recent advances, its mechanisms of pathogenesis are poorly understood. A unique feature of this pathogen is that, with some exceptions, it lacks homologs of known virulence factors from other pathogens. Through a genetic screen, we have identified a C. jejuni homolog of the VirK family of virulence factors, which is essential for antimicrobial peptide resistance and mouse virulence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimicrobial Cationic Peptides / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Blood Bactericidal Activity
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COS Cells
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Campylobacter jejuni / drug effects*
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Campylobacter jejuni / pathogenicity*
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Chlorocebus aethiops
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DNA Transposable Elements
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Mice
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Microbial Viability
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Mutagenesis, Insertional
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Virulence
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Virulence Factors / genetics
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Virulence Factors / physiology*
Substances
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Antimicrobial Cationic Peptides
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Bacterial Proteins
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Cjj81176_1087 protein, Campylobacter jejuni
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DNA Transposable Elements
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Virulence Factors