Hyaline inclusion myopathy: unmasked by statin therapy

Muscle Nerve. 2009 Oct;40(4):657-61. doi: 10.1002/mus.21079.

Abstract

We report a case of a patient with history of alcohol abuse, treatment for hepatitis C and repeated strenuous physical activity who developed severe muscle pain and weakness during statin therapy. The symptoms persisted after discontinuation of the drug. The diagnosis of myopathy was made clinically and by electromyography. As his symptoms persisted a muscle biopsy was performed which showed inclusions consistent with hyaline inclusions. Hyaline inclusion myopathy is discussed in the context of this case with review of the literature.

Publication types

  • Case Reports

MeSH terms

  • Alcoholism / complications
  • Electromyography
  • Electrophysiology
  • Hepatitis C, Chronic / complications
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / drug therapy
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / drug therapy
  • Interferons / therapeutic use
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Muscle Weakness / chemically induced
  • Muscle Weakness / physiopathology
  • Muscle, Skeletal / pathology
  • Myositis, Inclusion Body / diagnosis*
  • Myositis, Inclusion Body / drug therapy
  • Myositis, Inclusion Body / physiopathology
  • Simvastatin / adverse effects*
  • Simvastatin / therapeutic use

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Interferons
  • Simvastatin