Abstract
DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Comment
MeSH terms
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Archaea / genetics
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Bacteria / enzymology
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Bacteria / genetics
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Bacterial Proteins / metabolism
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Chromosome Breakage*
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DNA Breaks, Double-Stranded
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DNA Repair / physiology*
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Eukaryotic Cells / metabolism
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Exodeoxyribonuclease V / metabolism
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Exodeoxyribonucleases / metabolism
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Mycobacterium / enzymology*
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Mycobacterium / genetics*
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Prokaryotic Cells / metabolism
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RecQ Helicases / metabolism
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Saccharomyces cerevisiae / enzymology
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Saccharomyces cerevisiae / genetics
Substances
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Bacterial Proteins
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Exodeoxyribonucleases
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AddAB enzyme
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recJ protein, Bacteria
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Exodeoxyribonuclease V
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RecQ Helicases