The incidence of persistent sciatic artery (PSA) was evaluated in the setting of uterine artery embolization (UAE) for symptomatic uterine leiomyomata over a 3-year period. PSA was present in 0.83% of patients or 0.69% of limbs undergoing UAE at a single institution. The authors present three cases of PSA in which successful treatment with UAE was performed. Interventionalists should have thorough anatomic knowledge of PSA, and this rare yet important anatomic variant should be included among the pertinent findings during UAE.