Abstract
CD4+ T(H)17 cells display a featured role in barrier immunity. This effector population of T cells is important for clearance of microorganisms but can also promote autoimmunity at barrier sites. Recent work has indicated that these effector cells share a pathway with CD4+ regulatory T cells (T(R) cells) that also have a critical function in barrier protection and immune regulation. The development and function of T(H)17 cells, and their relationship with T(R) cells are discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism*
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CD4-Positive T-Lymphocytes / pathology
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Cell Differentiation
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Gastrointestinal Tract / immunology*
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Gastrointestinal Tract / pathology
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Humans
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Immunity, Cellular
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Immunity, Mucosal
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Infections / immunology
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Interleukin-17 / chemistry
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Interleukin-17 / immunology*
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Interleukin-17 / metabolism*
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Lung / immunology*
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Lung / pathology
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Signal Transduction
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Skin / immunology*
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Skin / pathology
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T-Lymphocytes, Regulatory / immunology
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Transcriptional Activation