BRCTing up is hard to do

Mol Cell. 2009 Jan 30;33(2):137-8. doi: 10.1016/j.molcel.2009.01.005.

Abstract

In this issue of Molecular Cell, Usui et al. (2009) show that Mec1-phosphorylated Rad9 SCD interacts with the BRCT domain, promoting oligomerization. This sustains the DNA damage checkpoint and is suppressed by Rad53 phosphorylation in a negative feedback circuit.

Publication types

  • Comment

MeSH terms

  • DNA Damage / physiology*
  • DNA Repair / physiology*
  • Models, Biological
  • Phosphorylation
  • Protein Structure, Tertiary