Abstract
Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amyloid beta-Protein Precursor / genetics
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Amyloid beta-Protein Precursor / metabolism
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Animals
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Humans
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Immune System / physiology
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Muscle Proteins / genetics
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Muscle Proteins / metabolism
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Myositis, Inclusion Body* / pathology
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Myositis, Inclusion Body* / physiopathology
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Myositis, Inclusion Body* / therapy
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Review Literature as Topic
Substances
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Amyloid beta-Protein Precursor
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Muscle Proteins