In this issue of Developmental Cell, Lyu and colleagues (2008) report that cleavage of Ryk, a transmembrane Wnt receptor, and the nuclear translocation of its intracellular domain (ICD) are essential for neuronal differentiation during mouse cortical neurogenesis. Their findings point to the possibility that Ryk, an atypical receptor tyrosine kinase, directly regulates Wnt target gene expression.