DNA double-strand break processing: the beginning of the end

Steven Raynard; Hengyao Niu; Patrick Sung

doi:10.1101/gad.1742408

DNA double-strand break processing: the beginning of the end

Genes Dev. 2008 Nov 1;22(21):2903-7. doi: 10.1101/gad.1742408.

Authors

Steven Raynard¹, Hengyao Niu, Patrick Sung

Affiliation

¹ Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3' ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767- 2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
DNA Breaks, Double-Stranded*
DNA Helicases / metabolism
DNA Ligases / metabolism
DNA Repair / physiology*
DNA Replication / physiology*
Evolution, Molecular
Exodeoxyribonucleases / metabolism
Humans
Recombinases / metabolism
Recombination, Genetic
Synapses / physiology

Substances

Recombinases
Exodeoxyribonucleases
DNA Helicases
DNA Ligases