Cutaneous T cell lymphoma: translating immunobiology into therapeutic opportunities

C L Berger; P Heald; M Girardi; R L Edelson

Cutaneous T cell lymphoma: translating immunobiology into therapeutic opportunities

G Ital Dermatol Venereol. 2008 Feb;143(1):43-54.

Authors

C L Berger¹, P Heald, M Girardi, R L Edelson

Affiliation

¹ Department of Dermatology, School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06520, USA carole.berger@yale.edu

PMID: 18833050

Abstract

Cutaneous T cell lymphoma (CTCL) has always served as a proving ground where conceptual advances in immunology can be tested and the results translated into clinical practice. From the earliest studies that used sheep red blood cells to identify the malignant cell as a T lymphocyte to molecular demonstration of the clonalilty of the disease, basic science techniques have provided sign posts that allow us to understand the clinical features seen in the patients. We continue to apply this paradigm to develop new insights into the role of the immune system in CTCL with the goal of using this knowledge to enhance the therapeutic options available to the patient. This article will review the studies that have led to our current understanding of the immunobiology of CTCL and the new therapeutic approaches that are being tested in this disease.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Animals
Antibodies, Monoclonal / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Apoptosis
Bexarotene
Clone Cells / immunology
Clone Cells / pathology
Cytokines / therapeutic use
Dendritic Cells / immunology
Dendritic Cells / pathology
Diphtheria Toxin / therapeutic use
Gene Expression Regulation, Neoplastic
Humans
Immunophenotyping
Interleukin-2 / therapeutic use
Lymphoma, T-Cell, Cutaneous / drug therapy
Lymphoma, T-Cell, Cutaneous / genetics
Lymphoma, T-Cell, Cutaneous / immunology
Lymphoma, T-Cell, Cutaneous / pathology
Lymphoma, T-Cell, Cutaneous / therapy*
Mice
Neoplastic Stem Cells / immunology
Neoplastic Stem Cells / pathology
PUVA Therapy
Photopheresis / instrumentation
Photopheresis / methods
Recombinant Fusion Proteins / therapeutic use
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / pathology*
T-Lymphocytes, Regulatory / immunology
T-Lymphocytes, Regulatory / pathology
Tetrahydronaphthalenes / administration & dosage

Substances

Adrenal Cortex Hormones
Antibodies, Monoclonal
Cytokines
Diphtheria Toxin
Interleukin-2
Recombinant Fusion Proteins
Tetrahydronaphthalenes
denileukin diftitox
Bexarotene