What can population calcium imaging tell us about neural circuits?

J Neurophysiol. 2008 Dec;100(6):2977-80. doi: 10.1152/jn.91037.2008. Epub 2008 Oct 1.

Abstract

Calcium imaging of bulk-loaded fluorescent indicators can be used to record the spiking activity of hundreds of neurons. Recent advances promise imaging technologies that are faster, more efficient, and applicable to awake animals, thereby moving imaging capabilities closer to the traditional strengths of multi-electrode arrays. This article reviews these technical achievements and discusses how they can help us achieve the goal of understanding neural circuits.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling / physiology
  • Diagnostic Imaging / methods*
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Wakefulness / physiology

Substances

  • Calcium