Keeping 'trk' of antidepressant actions

Neuron. 2008 Aug 14;59(3):349-51. doi: 10.1016/j.neuron.2008.07.028.

Abstract

Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adult neurogenesis are necessary for the behavioral actions of antidepressants in rodents, the cellular mechanisms involved in these effects are still unknown. Li et al. in this issue of Neuron demonstrate that the presence of TrkB, the high-affinity receptor for BDNF, in hippocampal neural progenitor cells is required for the neurogenic and behavioral actions of antidepressant treatments.

Publication types

  • Comment

MeSH terms

  • Adult Stem Cells / drug effects
  • Animals
  • Antidepressive Agents / pharmacology*
  • Cell Proliferation / drug effects*
  • Mice
  • Neurons / drug effects
  • Receptor, trkB / metabolism*

Substances

  • Antidepressive Agents
  • Receptor, trkB