Abstract
In young women, estradiol and progesterone primarily control reproduction, but they also affect fluid regulation. Estradiol lowers the operating point for osmoregulation of arginine vasopressin and thirst and increases plasma volume. Although total body water and sodium content are only mildly affected, data presented in this article suggest that reproductive hormones alter homeostatic set points for body fluid and tonicity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Arginine Vasopressin / drug effects
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Body Fluids / drug effects*
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Estradiol / physiology*
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Female
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Gonadotropin-Releasing Hormone / administration & dosage
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Gonadotropin-Releasing Hormone / analogs & derivatives
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Gonadotropin-Releasing Hormone / antagonists & inhibitors
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Homeostasis / drug effects
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Humans
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Leuprolide / administration & dosage
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Leuprolide / antagonists & inhibitors
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Male
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Progesterone / physiology*
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Saline Solution, Hypertonic
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Sodium
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Thirst
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Water-Electrolyte Balance / drug effects
Substances
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Saline Solution, Hypertonic
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Arginine Vasopressin
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Gonadotropin-Releasing Hormone
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Progesterone
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Estradiol
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Sodium
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Leuprolide
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