LOT: a tool for linkage analysis of ordinal traits for pedigree data

Bioinformatics. 2008 Aug 1;24(15):1737-9. doi: 10.1093/bioinformatics/btn258. Epub 2008 Jun 5.

Abstract

Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage.

Availability: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Chromosome Mapping / methods*
  • Computer Simulation
  • Genetic Linkage / genetics*
  • Models, Genetic*
  • Pedigree*
  • Software*