Type 3 deiodinase in hypoxia: to cool or to kill?

Sabrina Diano; Tamas L Horvath

doi:10.1016/j.cmet.2008.04.008

Type 3 deiodinase in hypoxia: to cool or to kill?

Cell Metab. 2008 May;7(5):363-4. doi: 10.1016/j.cmet.2008.04.008.

Authors

Sabrina Diano¹, Tamas L Horvath

Affiliation

¹ Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. sabrina.diano@yale.edu

PMID: 18460327
DOI: 10.1016/j.cmet.2008.04.008

Abstract

Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3'-triiodothyronine (T3) and oxygen consumption, suggesting that D3 activation is a component of cellular responses to hypoxia and supporting the idea of cell-specific regulation of thyroid hormone levels by deiodinases.

Publication types

Editorial

MeSH terms

Animals
Enzyme Activation
Humans
Hypoxia / enzymology*
Hypoxia-Inducible Factor 1 / physiology
Iodide Peroxidase / metabolism*
Signal Transduction
Up-Regulation

Substances

Hypoxia-Inducible Factor 1
iodothyronine deiodinase type III
Iodide Peroxidase