Abstract
The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites. In both in vitro and in vivo assay systems, ritonavir was found to be the most potent in potentiating the antimalarial action of chloroquine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / administration & dosage*
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Atazanavir Sulfate
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Chloroquine / administration & dosage*
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Drug Resistance
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Drug Synergism
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Female
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HIV Protease Inhibitors / administration & dosage*
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Humans
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In Vitro Techniques
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Lopinavir
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Malaria / drug therapy
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Malaria / parasitology
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Mice
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Nelfinavir / administration & dosage
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Oligopeptides / administration & dosage
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Plasmodium chabaudi / drug effects*
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / growth & development
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Pyridines / administration & dosage
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Pyrimidinones / administration & dosage
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Ritonavir / administration & dosage
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Saquinavir / administration & dosage
Substances
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Antimalarials
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HIV Protease Inhibitors
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Oligopeptides
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Pyridines
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Pyrimidinones
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Lopinavir
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Atazanavir Sulfate
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Chloroquine
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Nelfinavir
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Saquinavir
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Ritonavir