Modulation of apoptosis to reverse chemoresistance

Gil Mor; Michele K Montagna; Ayesha B Alvero

doi:10.1007/978-1-59745-339-4_1

Modulation of apoptosis to reverse chemoresistance

Methods Mol Biol. 2008:414:1-12. doi: 10.1007/978-1-59745-339-4_1.

Authors

Gil Mor¹, Michele K Montagna, Ayesha B Alvero

Affiliation

¹ Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

PMID: 18175807
DOI: 10.1007/978-1-59745-339-4_1

Abstract

Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

Publication types

Evaluation Study
Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Apoptosis / drug effects
Apoptosis / genetics*
Apoptosis / physiology*
Chemotherapy, Adjuvant
Drug Resistance, Neoplasm* / drug effects
Drug Resistance, Neoplasm* / genetics
Gene Expression Regulation, Neoplastic
Humans
Inhibitor of Apoptosis Proteins / physiology
Isoflavones / pharmacology
Isoflavones / therapeutic use
Models, Biological
Neoplasms / drug therapy
X-Linked Inhibitor of Apoptosis Protein / genetics

Substances

Antineoplastic Agents
Inhibitor of Apoptosis Proteins
Isoflavones
X-Linked Inhibitor of Apoptosis Protein
phenoxodiol