Abstract
Seventeen non-treatment seeking cocaine-dependent individuals participated in three-week longitudinal inpatient studies of cognitive changes during drug use and abstinence. Protocols included three days drug-free baseline, three days cocaine self-administration, and two weeks complete abstinence. A repeatable cognitive battery showed attention and delayed verbal recognition memory but not working memory to be impaired in cocaine users compared to age- and sex-matched normative values. Attention was significantly poorer during the first and second week of abstinence compared to days on which cocaine was used suggesting that certain cocaine-induced impairments may be acutely normalized by cocaine use, but resurface during abstinence.
Publication types
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Comparative Study
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Multicenter Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Attention / drug effects
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Clinical Protocols
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Cocaine-Related Disorders / diagnosis*
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Cocaine-Related Disorders / epidemiology
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Cocaine-Related Disorders / psychology*
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Cognition Disorders / diagnosis*
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Cognition Disorders / psychology*
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Connecticut / epidemiology
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Crack Cocaine / administration & dosage
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Crack Cocaine / pharmacology
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Female
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Humans
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Longitudinal Studies
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Male
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Neuropsychological Tests / statistics & numerical data*
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New York / epidemiology
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Reference Values
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Self Administration
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Smoking / psychology
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Substance Withdrawal Syndrome / epidemiology
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Substance Withdrawal Syndrome / psychology*